brain injury

Rapid relief of 4 years of debilitating stroke pain after treatment by Dr. Tobinick October 2022

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by INR PLLC

Perispinal etanercept treatment by Dr. Tobinick 4 1/2 years after stroke. Immediate and sustained relief of constant, daily, debilitating central post-stroke pain that had lasted more than 4 1/2 years. The central stroke pain had followed a thalamic stroke in 2018, and had been present 24/7 and failed to adequately respond to all previous drug treatment (Thalamic Pain Syndrome). Filmed October 6, 2022, at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

2 patients discuss the amazing change in their chronic stroke pain after treatment by Dr. Tobinick

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by INR PLLC

Filmed October 13, 2022, at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Wow! Sustained ability to return to daily activities after stroke treatment by Dr. Tobinick

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by INR PLLC

First, a disclaimer: Although this video is an accurate description of this patient’s remarkable response to treatment, with significant and sustained improvement in a wide variety of chronic stroke symptoms, it is exceptional and rare that patients with severe chronic symptoms are able to return to this degree to normal daily activities after treatment. Treatment response was immediate and sustained for months, and included improvements in vision, aphasia, balance, motor function, brain fog, etc. Regained was the ability to return to normal daily activities, including driving, day and night; cooking; computer work; keeping a checkbook; making reservations, etc. After treatment, leg strength and balance improved, the ability to go up and down stairs without using the handrail returned, peripheral vision improved, shoulder range of motion improved, brain fog went away, and speech improved.

Filmed at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida, on September 16, 2022.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Life-changing improvements 26 years after TBI following a single treatment by Edward Tobinick, M.D.

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by INR PLLC

Life-changing Improvements, including improvements in vision, chronic pain, motor control, balance, and swallowing after a single treatment, given 26 years after a car crash causing severe traumatic brain injury.

Filmed August 4, 2022, at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Seizure reduction; improvement in stamina, cognition, and spasticity after treatment by Dr. Tobinick

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Seizure reduction, with immediate improvement in stamina, cognition, and spasticity following treatment by Edward Tobinick, M.D., 7 years after traumatic brain injury. Filmed at the Institute of Neurological Recovery in Boca Raton, Florida, in October, 2021.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Immediate improvement 16 years after brain injury following treatment by Edward Tobinick, M.D.

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Perispinal etanercept treatment by Dr. Tobinick. Filmed at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida, on March 3, 2021. Text, images and video © 2021, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Immediate improvement 4 yrs. post-TBI after treatment by Edward Tobinick M.D.

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Immediate improvement in central pain, cutaneous hypersensitivity, walking, spasticity and balance following a single dose of perispinal etanercept. Treatment by Dr. Tobinick at the Institute of Neurological Recovery (INR®) in Boca Raton, Florida, on October 30, 2020, 4 years after traumatic brain injury and stroke caused by a motorcycle accident.

Text, images and video © 2020, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

From Denmark to the INR in Boca Raton, Florida, March 2018. Immediate and sustained improvement, two years after traumatic brain injury from a skiing accident.

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by INR PLLC

She has written an update on her progress! See it here!

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Perispinal Etanercept for Traumatic Brain Injury

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by INR PLLC

“Perispinal Etanercept for Traumatic Brain Injury” is Chapter 7 of the medical textbook New Therapeutics for Traumatic Brain Injury. See the abstract and links below:

“Abstract
Brain dysfunction after traumatic brain injury (TBI) may involve a persistent neuroinflammatory response that can last for years following acute brain insult. This neuroinflammatory response may include microglial activation and persistence of excess levels of tumor necrosis factor (TNF) in the brain, resulting in perturbation of brain function. TNF, in addition to its role as the master regulator of the inflammatory response, is a key regulator of synaptic function in the brain. Experimental data suggest that etanercept, a selective TNF inhibitor, may ameliorate microglial activation; modulate the adverse synaptic effects of excess TNF; and favorably intervene in basic science models of TBI, stroke, subarachnoid hemorrhage, and Alzheimer’s disease. Perispinal administration is a therapeutic method designed to use the cerebrospinal venous system to enhance selective delivery of etanercept across the blood–cerebrospinal fluid barrier. Increasing clinical data suggests that perispinal etanercept (PSE) has therapeutic utility for treatment of selected brain disorders associated with elevated TNF, including chronic neurological dysfunction following stroke and various forms of brain injury. PSE is an emerging treatment modality for TBI.”

Rapid Improvement in Gait 8 years after Severe Traumatic Brain Injury at the INR, March 2017

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Traumatic Brain Injury 8 years prior, gait improvement after treatment at the INR in Boca Raton in March 2017.

Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment for these indications is innovative (“off-label”). Please see the Terms of Use. The method of off-label treatment utilized is a patented invention of the INR. Copyright 2017 INR PLLC, all rights reserved.

Scientific literature provides support for the scientific rationale. See: